Conclusions/Significance. As in other studies, we find secondary disease to be strongly associated with DHF and with more severe grades of DHF. DENV-2 appears to be marginally associated with more severe dengue disease as evidenced by a significant association with DHF grade I when compared to DENV-1.

Which serotype of dengue is more dangerous?

In addition, certain dengue strains, particularly those of DENV-2, have been proposed to be more virulent, in part because more epidemics of dengue hemorrhagic fever have been associated with DENV-2 than with the other serotypes.

What is the difference between the 4 dengue serotypes?

All Answers (3) The difference is based on antibody reactions to surface antigens on the virus. Each serotype has subtle differences in their surface proteins, meaning that different antibodies are produced to bind to those proteins.

What is serotype 2 dengue?

Dengue serotype 2 (DEN-2) viruses with the potential to cause dengue hemorrhagic fever have been shown to belong to the Southeast (SE) Asian genotype. These viruses appear to be rapidly displacing the American genotype of DEN-2 in the Western Hemisphere.

Is severe dengue DHF?

Some patients with dengue fever go on to develop dengue hemorrhagic fever (DHF), a severe and sometimes fatal form of the disease. Around the time the fever begins to subside (usually 3–7 days after symptom onset), the patient may develop warning signs of severe disease.

Novel vaccine approach to combat Dengue virus

WHO dengue 2009 classification?

Dengue classification according to the World Health Organization guidelines issued in 2009. Dengue is classified as dengue with or without warning signs and severe dengue. Diagnosis of dengue requires the presence of fever and at least 2 clinical findings or any warning signs.

Is dengue transmitted by kissing?

An infected mosquito can later transmit that virus to healthy people by biting them. Dengue cannot be spread directly from one person to another, and mosquitoes are necessary for transmission of the dengue virus.

What is a serotype of a virus?

Serotypes are groups within a single species of microorganisms, such as bacteria or viruses, which share distinctive surface structures.

How many dengue serotypes are there?

The virus responsible for causing dengue, is called dengue virus (DENV). There are four DENV serotypes, meaning that it is possible to be infected four times. While many DENV infections produce only mild illness, DENV can cause an acute flu-like illness.

How dengue serotypes are present in India?

Dengue viruses (DV) belong to family Flaviviridae and there are four serotypes of the virus referred to as DV-1, DV-2, DV-3 and DV-4.

How is dengue serotype determined?

Dengue was confirmed and serotype determined by real-time reverse transcription-polymerase chain reaction (RT-PCR) using an in-house protocol using the samples from the first day of presentation.

Why platelets are low in dengue?

When an infected mosquito bites a human, the dengue virus enters the bloodstream, it binds to platelets and replicates leading to multiplication of infectious virus. The infected platelet cells tend to destroy normal platelets which is one of the major causes for the drop in the platelet count in dengue fever.

Why is secondary dengue infection worse?

People who are infected a subsequent time with a different type of the dengue virus may experience something called "antibody-dependent enhancement." This condition occurs when the immune response actually makes the clinical symptoms of dengue worse, increasing the risk of severe dengue.

Which serotype causes dengue hemorrhagic fever?

Dengue is a disease caused by a RNA virus of the family Flaviviridae, caused by four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) which are genetically and antigenically distinct. The virus is transmitted to humans by a bite from an infected mosquito of species Aedes aegypti and Aedes albopictus [1].

Which serotype of dengue is most common in India?

Dengue virus serotypes were tested in 4963 samples collected across India in 2018. DENV-2 was the most prevalent serotype in many states of India. Two genotypes of DENV-1 (I and V) were circulating.

What does NS1 positive mean?

A positive NS1 test result confirms dengue virus infection without providing serotype information. A negative NS1 test result does not rule out infection. People with negative NS1 results should be tested for the presence of dengue IgM antibodies to determine possible recent dengue exposure.

Where is dengue most common?

The disease is common in many popular tourist destinations in the Caribbean (including Puerto Rico), Central and South America, Southeast Asia, and the Pacific Islands. In the United States, local cases and limited spread of dengue does occur periodically in some states with hot, humid climates and Aedes mosquitoes.

Is Dengue Fever localized or systemic?

Dengue is a vector-borne, systemic viral infection and a globally important public health problem. Dengue is transmitted predominantly by the mosquito Aedes aegypti, which bites in the daytime, is adapted to human habitats and has a preference for human blood meals.

Can you get dengue twice?

It is possible to get dengue more than once. Dengue is caused by a virus which has four different strains. Being affected by one strain offers no protection against the others. A person can suffer from dengue more than once in her/his lifetime.

What is AAV serotype?

AAV Serotypes

These serotypes differ in their tropism, or the types of cells they infect, making AAV a very useful system for preferentially transducing specific cell types. The chart below gives a summary of the tropism of AAV serotypes, indicating the optimal serotype(s) for transduction of a given organ.

How do you do a serotype?

Serotyping is typically performed by slide agglutination using sets of O, H and K antisera, and the resulting combination of antigens defines the serotype (also called serovar).

Is a serotype the same as a strain?

That strain has demonstrably different properties from the human strain. There are other terms to describe viruses but they are more confusing than contentious, and they are not used universally. The term serotype is used to describe viruses of the same species that are antigenically different.

Is dengue contiguous in India?

OUTBREAK. India has confirmed Dengue cases with cases reported from across the country. Dengue is endemic in India. Transmission occurs year-round in southern areas and from April through November in northern states.

Who is the carrier of dengue virus?

The carrier incriminated throughout most endemic areas is the yellow-fever mosquito, Aedes aegypti. The Asian tiger mosquito, A. albopictus, is another prominent carrier of the virus.

Can any mosquitoes carry dengue?

Only the female Aedes aegypti mosquitoes can spread the dengue virus and in fact, these mosquitoes can transfer the infection only when they themselves are infected. So, no need to panic after each mosquito bite.