Gingival enlargement is one of the side effects associated with certain drugs. Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia.

Can amlodipine cause gum hyperplasia?

Gingival overgrowth is an adverse drug reaction of new-generation CCB Cilnidipine when administered even as low-dose antihypertensive therapy agent. Physicians and dentists should identify such late changes in susceptible individuals.

How common is gingival hyperplasia with amlodipine?

Amlodipine is a second-generation dihydropyridine calcium channel blocker that can cause gingival hypertrophy. The prevalence of amlodipine-induced gingival hypertrophy has been shown to be between 1.7% and 3.3%.

Which medication will cause gingivitis hyperplasia?

• Phenytoin.
• Phenobarbital.
• Lamotrigine.
• Vigabatrin.
• Ethosuximide.
• Topiramate.
• Primidone.
• Nifedipine.

Why do calcium channel blockers cause gingival hyperplasia?

The present study proposes a mechanism by which calcium channel antagonists may induce gingival hyperplasia. The calcium antagonist induces blockage of the aldosterone synthesis in zona glomerulosa of the adrenal cortex since this pathway is calcium-dependent, cyclic nucleotide-independent.

Management of Amlodipine-Induced Gingival Enlargement in Hypersensitive Patient with Gingivectomy

Does amlodipine affect your gums?

Gingival enlargement is one of the side effects associated with certain drugs. Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia.

Is there an alternative to amlodipine?

There are several other calcium channel blockers that work in the same way as amlodipine. They include nifedipine, felodipine, lacidipine and lercanidipine. There are other calcium channel blockers, such as diltiazem and verapamil, that have other effects on the heart.

How do you reverse gingival hyperplasia?

Gingival hyperplasia can be resolved by improving oral hygiene habits. In more severe cases, surgical treatment is necessary.
...
Treating gingival overgrowth

1. Laser excision. A periodontist will use lasers to remove inflamed gum tissue. ...
2. Electrosurgery. ...
3. Periodontal flap surgery. ...
4. Gingivectomy.

Which of the following medications is most commonly associated with gingival enlargement?

A: The most commonly implicated drugs associated with gingival enlargement are: 1. Phenytoin: an anticonvulsant medication used to treat various types of seizures and convulsions.

How do you get rid of gingival hyperplasia at home?

1. Brush your teeth at least twice a day. ...
2. Opt for an electric toothbrush to maximize your cleaning potential.
3. Make sure your toothbrush has soft or extra-soft bristles.
4. Replace your toothbrush every three months.
5. Floss daily.
6. Use a natural mouthwash.
7. Visit your dentist at least once a year.

Why is amlodipine banned in Canada?

The affected medication may contain traces of N-nitrosodimethylamine (NDMA), a “probable human carcinogen” that could increase the risk of cancer through long-term exposure above acceptable levels, Health Canada says.

How long does it take for gingival hyperplasia to go away?

How long does it take for gingival hyperplasia to go away? After you stop taking the medication(s) that caused gingival hyperplasia or start treatment for the condition, it takes one to eight weeks for the lesions to disappear.

Can blood pressure tablets cause bleeding gums?

The most commonly prescribed medications that may lead to bleeding gums are blood pressure medications, blood thinners, and antidepressants.

Does amlodipine cause lip swelling?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, when you first start taking amlodipine, your angina may get worse or you could have a heart attack.

What are the side effects of amlodipine?

• swelling of the hands, feet, ankles, or lower legs.
• headache.
• upset stomach.
• nausea.
• stomach pain.
• dizziness or lightheadedness.
• drowsiness.
• excessive tiredness.

How long does it take for amlodipine to get out of your system?

In other words, it takes about 30 to 50 hours for your body to get rid of half of a dose of amlodipine. It usually takes about five half-lives for a drug to leave your system entirely. For amlodipine, this means the drug will stay in your system for about 10 days after your last dose.

What causes overgrowth of gum tissue?

Causes of Gum Overgrowth

Gum overgrowth usually occurs when your gum tissues respond aggressively to irritants like plaque or tartar. Instead of leading to receding gums, gum disease can trigger excessive growth of gum tissue, although receding gums may often follow.

What drugs cause inflammation of the gums?

• Phenytoin, a seizure medication.
• Cyclosporine, an immunosuppressant drug often used to prevent transplant rejection.
• Blood pressure medications called calcium channel blockers, which include nifedipine, verapamil, diltiazem, and amlodipine.

What is drug-induced gingival enlargement?

Drug-induced gingival overgrowth or enlargement manifests as abnormal growth of the gingiva due to an adverse drug reaction (ADR) in patients treated with anticonvulsants, immunosuppressants, and calcium channel blockers.

What is the treatment for gingival enlargement?

Treatment of tumor-like gingival enlargements consists of surgical excision, as well as the scaling and root planing of the tooth surfaces adjacent to the lesion. The enlargement may recur unless all irritants are removed.

What causes gingival papilloma?

Although oral squamous cell papilloma can affect tongue, skin, pharynx, larynx, and lip, its appearance on the gingiva is relatively rare. The etiology of this condition has been attributed to human papillomavirus (HPV), and the lesion progresses due to proliferation of the stratified squamous epithelium.

What does early stage gum disease look like?

In its early stages, inflammation around the gums is observable, with gum tissues appearing red and swollen. Gums that are easily irritated or that bleed during tooth brushing indicate the presence of Gingivitis. Removal of the plaque buildup is necessary to prevent the development of gum disease.

Why amlodipine is bad for you?

It comes with serious risks if you don't take it as prescribed. If you don't take it at all or stop taking it: If you don't take amlodipine or stop taking it, your blood pressure or chest pain may get worse. This could lead to serious problems, such as a stroke or heart attack.

What should you avoid when taking amlodipine?

Avoid eating foods high in fat or cholesterol, or this medicine will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and increase your risk of liver damage. Alcohol can also increase some of the side effects of amlodipine and atorvastatin.

What are the long term effects of taking amlodipine?

If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.